I know I will get flamed for this, but I'm going to say it anyways:
A re-boot would be nice, let the franshise take a break for about 5 years, then re-boot the whole thing. Sami Rami, while he does have a idea what spiderman is about, seems to have gotten caught up in a "I want to make the Spider-Man world my own" idea, where Spidey doesn't need a mask, and he can stand behind a whole crowd of people without it on, or save a speeding bus, and no one ever sees him, knows who he is, or is smart enough to report what he looks like and cash in on a reward. Also, Sandman really killed Ben Parker, and where Harry is neither the Green Goblin or the Hobgoblin, just some whacked out guy who threw rockets on his snowboard and missed the X-Games.
Also, Rami screwed Spider-Man in Spider-Man 1, by keeping Gwen Stacy out of the picture. Gwen's death had as big an impact as Uncle Ben's death on him and his personality. This would be along the same lines of only one of Bruce Waynes parents being murdered, but the other survived, it just doesn't work with the character.
Also, Rami doesn't get Spider-Man's personality. He nails Peter Parker, aside from the fact we don't see him invent anything, but when he puts on the Spider Man costume, he transforms, becomes a different, more confident person. Has anyone ever ready the script treatment for James Camerons Spiderman? He understood it, even had a great scene where Peter first put on the Spider Man mask, when he first made it, in his room, and started acting more confident and quipping lines, and Aunt May knocked on the door, and he yanked the mask off and was back to the meek, docile Peter Parker. THAT'S how Peter/Spidey should be, not pelvic thrusting down New York streets or being mute when fighting supervillians. (Cameron even had in his script Spidey had the organic web shooters, but Peter made mechanical ones to try to cover how he could shoot web to other people) Now, countering what I have said about Cameron, lest I get flamed on this, he had the Peter/MJ deal going from square one as well, no Gwen at all, so his was lacking this as well.
I'd love a reboot, give the series 5 years to cool off, and then restart it with a new director and cast, and start over from square one. Don't make Goblin a Power Ranger, don't make Spidey a mute, and for Pete's sake (no pun intended, or was it?) LEAVE SPIDEY'S MASK ON!!!! With clever lighting, the mask can be just as expressive as a persons face, if not more so. If Rami wants a hero who's face is always shown, have him go direct Green Arrow or something.
Anyways, enough of my rant. Spider-Man 3 (or Peter Parker 2, if you wish) about ruined my faith in Rami's Spidey movies, not because of that movie itself, but the problems and changes Rami has built up in his 3 films. 3 was bad, there is no way around it, it had the potential to be a good one, and I myself sat through the first 80 percent of the movie and thought it was awesome, but then they got to the final act, and it was like Rami though, Crap, I got here, but I have no idea how to end this movie. The ending felt disjointed and thrown together (I know Venom was thrown in there, but still) and I remember one review that has stuck with me, in SM1 and SM2, even though we knew it wasn't going to happen, you still felt like there was a chance that the villian would win. You never felt that in SM3, they got close when Venom was beating the mess out of Peter, but that was only about 5 seconds long before Pete caged Venom and then blew him up. But still, there were problems in all 3 of Rami's films, and when you look at his body of work, and where he is "rumored" to be wanting to go with the series if he stays, I'm not excited about SM4 at all, and I was looking forward to SM3 from the moment the final credits rolled to 2.
But these are just my own, personal opinions. Flame away, if need be.