I'm also hoping for an awesome freeroam 616 game. Or partial freeroam atleast. But they basically need to scrap the whole combat system from shattered dimensions. They need a more mature, controlled set of moves. I'd constantly hear spidey say 'hooray for violence' in SD, and it made me think that spidey shouldn't be about violence, he's more about preventing violence.
They should focus more on bullet dodging and quickly closing gaps between you and an enemy. One or two punches should handle most, he doesn't need to constantly administer moves that would kill or paralyze people.
The effort should be more in landing the punch while avoiding the knives and guns. And the webshooters should be more useful as long range weapons and as a way to permanently disarm enemies. I imagine a scenario like this:
From a distance, behind cover or at a hight point, you observe a group of three enemies standing around a hostage. The enemy closest to the hostage has a gun, and will shoot them if they see you approach.
From a distance, you shoot a (long range) web projectile at the enemy with the gun, knockin it out of his hand. You dive into the room and plant a kick on the same enemies chest, backflipping off of him and knocking him to the ground. As soon as you touch the ground, a second enemy swings at you, you dodge and knock him out with one punch. You notice the third guy going for the gun. You switch web types, and proceed to fire a medium range stream of webbing that binds his arms and legs. He falls to the ground in front the gun defeated. You rescue the hostage and done.
So basically the fights are shorter but sweeter.