Just for fun, I'll list similarities and differences between Raimi's trilogy and Webb's film storywise
Similar:
1. Peter Parker is a nerd and outcast
2. The film starts with him at school
3. Peter gets bitten by a radioactive spider by an accident
4. Peter becomes a superhero after the death of Uncle Ben
5. Spider-man can crawl walls and use spider's sense
6. The villain is related to Oscorp
7. Peter and the character that yet to become the main villain have connection prior to their transformations
Differences:
1. Raimi's spends only one act till Peter becomes a professional superhero, while Webb's will explore his development in the span of the entire film
2. Raimi's has Peter graduating from high school and landing a job right after the first act, while Webb's keeps Peter at school for the entire film
3. In Raimi's Peter has no interest in discovering the truth about his parents (they were mentioned only once actually), while Webb's gets in details in order to explain why Peter is who he is and thus includes the mystery of his parents' fate in the film
4. Raimi's Spider-man has a costume more faithful to comics, yet being too ideal. Webb's Spider-man has a costume more grounded and realistic (it's more possible for a ttenager to come up with it than in Raimi's)
5. In Raimi's MJ plays the role of love interest, combining characteristics of MJ, Gwen and Liz from comics at once. In Webb's it's Gwen, and a pretty faithful adaptation
6. Raimi's starts the story of Osborns, figuring as important characters, from the beginning. In Webb's they are replaced by the Stacy clan
7. Raimi's never really gave the space for Connors to shine. Webb's will develop him to the point of transformation in the Lizard
8. Raimi's has Spider-man being established pretty fast, while Webb's is going with slower, yet more detailed and explained route of who Peter was, who Peter is and who is soon to become
9. Raimi's dialogues, tone and characterization is similar to comics, while Webb's seems like being more down to our reality and natural
10. Raimi's is more focused on Peter's relationships with other characters, whereas Webb's is all about Peter and his inner self against the outside surrounding
11. Raimi's has organics, Webb's - web-shooters
12. Raimi's spends more time in his films, showing how Peter ends as Spider-man. Webb's will concentrate on how he begins as Spider-man
13. Raimi's Parker is almost flawless, too generous and idealist, almost never makes mistakes. Webb's is more real and tangible, the one who would surely make a few mistakes before understanding how to do right. He acts like typical teenagers of these days.
14. While Raimi's Peter is lead to the spider's bite by an accident, Webb's Peter takes himself to Oscaorp, motivated by his own intentions to discover something. To note again, the bite itself still remains accidential in both
15. In Raimi's the relationship between Ben and Peter has a greater value prior to Ben's death, while, as I believe, in Webb's Peter realizes Ben's significance only after the death
15 against 7.
One imprtant thing to note is that the major thing that distinguishes Webb's from Raimi's is Peter Parker himself. His personality, motives, arc and choices he makes. We all know the story of how he becomes Spider-man, but this doesn't come from Raimi's films. It comes from Amazing Fantasy #15. Moreover, what's critical here is how the path for Peter to superhero lies in this one. Surely, this time we have different characters, different tone and even different actions and reasons for Peter, which already sets a new vision for the film.
BTW, I hope I haven't missed anything. But, if you have any more ideas, please, speak out.
P.S. I'd like to apologize in case I have some errors in my post. I was typing very fast and English isn't my first language