Here is a good question, how should Mole Man be characterized in this film? I find Mole Man kinda of a one note character in the 616 universe, he seems to want revenge on the world because a few women who were out of his league didn't go out with him and his boss fired him for being ugly. You think he could have lowered his standards a bit or sued his boss or something. Neither the women nor the boss are developed enough to provide any real meat to Mole Man's back story, if there was a particular woman who broken his heart in a particularly cruel way, that would provide more depth. Nora Fries has more developed then those back ground characters and she is just a woman in a chronological stasis tube.
At least in the Ultimate Universe, he had a reason to hate the US government, so he had a particular grudge against a particular party who he felt had wronged him, rather then wanting on the wold because of the actions of a few, that motive would have only worked if Mole Man is supposed to be a psychopathic monster. Is Mole Man supposed to be a sympathetic villain or a psychopathic monster?
Also I liked the creepy obsession Ultimate Mole Man had with Sue. The problem with 616 Mole Man is, their are hardly any issues that explore his character, rather then having him engage in generic super villain plots. Heck, Mark Waid was the first person in a long time to have a story where we get to see what makes Mole Man tick, but he did it in an issue of DD, in a story that is so tied to DD it doesn't work as a FF story.
I actually think Mole Man is a good starter villain for the FF, I wouldn't mind Doom just being in the background, manipulating things, but he needs more characterization then he generally gets in the 616 comics to carry a movie.