Sister, Sister - The girls are offered to be a model for some guy but don't tell their parents. When they get to the guy's house, he pretty much wants them to take off their clothes. Now that I think about it, I think only one of them went and the other was suspicious about it all.
It was something like that? Dealt with sexual predators I'd assume.
Was there ever a Growing Pains that dealt with the girl's weight problems? I know Tracey Gold battled with either Anorexia or Bullimia, but was it ever covered on the show? I'd assume not, but you never know.
I have only seen a few episodes of the show, but I think Facts of Life had a LOT of very special episodes. Dealing with losing their virginity was one of them I think (that's just because I saw some VH1 special.)
Kimmy Gibler gets drunk in an episode of Full House. I guess that qualifies.