SONY is backed into a corner. They don't have many options if this fails. My biggest concern is that if this fails, it also affects the MCU. However, there are some points to take into account. I think Marvel/SONY will play it safe here. Granted, casting an actual teenager is not playing it safe, but other than that. Storywise they'll play it safe. No parents subplot with hints at destiny or anything like that. They'll likely stay very true to the source material of the 60s-70s comics when it comes to the origin, the characters etc. I think we're likely to get a Peter Parker / Spider-Man done right.
The thing that I can see might fail is the film quality as a whole, like Iron Man 2 and Thor: The Dark World. In that case, yeah Spider-Man is in a bad position but not in a way that ruins him or the MCU. Much like Thor hasn't been ruined by The Dark World. As long as they stay true to the characters so there's not a NEED to reboot again.