I myself would love to see Joss Whedon's take on Spidey. I guess he would be my 1# choice, but I know that's almost impossible, unless Spidey comes back to Marvel Studios - which is also almost impossible, at least by now. Matthew Vaughn would great, too, but I guess he's too much a Fox and he probably wouldn't do more than one movie. Edgwar Wright, Brad Bird, Duncan Jones, Rian Johnson, Abrams and Miller & Lord all seem very good. I'd also be down with a comeback from Raimi, but that's a really long shot.
All things, said, Drew Goddard seems to be the most logical choice and he sure would please me based on Cabin in the Woods. Marvel Studios also seem to trust him, as he is to write and direct Daredevil miniseries. I think his take could be great.
Now, the real best choice is, obviously, me!

t: I'd put Spidey on war between two crime factions led by Hammerhead and Mysterio. Spidey would have to play the detective and would first come to Hammerhead. A lot of investigation and interrogations would have to take place to find the shady figure that is Mysterio, who would screw up Spidey's head badly with some nasty illusions. If you guys like my ideia, please send e-mails to Sony requesting them to hire me.

t: