This movie is almost maxing it's BO potential. It's not like it has the mass appeal of Superman, Spider-Man, Batman and Iron Man. The chicks mainly are biased towards the character and have little interest, if not draged to the cinema. And the chicks make out a big deal of the BO, it also has an effect on families. No matter how great an Hulk-movie, it just is not as tempting for families and chicks.
It did not open as good as 2003 Hulk, but it has better legs and smaller drops and will probably make more then that by a 5-10 millions.
Internationally it looks like it is going to make much more then 2003 Hulk. European Soccer championship is hurting it a little, but not to much.
This seems to be a profit for Marvel, all in all. It will not do anything with their Avengers plan, and I doubt it will have any impact on Hulk II.