The point of the framework was to create a world where a regret is removed or whatever...so memories of your actual life HAS to be erased, so you can be at square one. May's obviously had a domino effect on the world, as did Coulson's etc. You are talking as if it is established that he is brainwashed...but when I asked for some sort of evidence you fell to "who knows what else she did." The framework design isn't about brainwashing...it's about removing memories and allowing you to set a different course based on wishes, regrets etc...that your virtual self and the virtual world then has to adjust to.
So explain how he does not remember Simmons / being friends with Skye & co without the brain washing reasoning ?