Without the gauntlet, it's possible that Hulk could build enough rage strength to get a lucky punch on Thanos and get him off his feet, but don't forget that Thanos without anything is much stronger than Hulk and much more intelligent and strategic than the majority of the beings in the universe, so it would be difficult for Hulk to do much beyond taking Thanos off his feet once or twice.
For reference, Thanos in the recent Infinity story took out Black Bolt and the. entire Avengers team by himself without any power enhancers, and in Infinity Revelation he destroyed Ronan, Gladiator, Silver Surfer, and many others without breaking a sweat.
It seems Marvel may even be supercharging Thanos for the MCU as well, with Korath calling him "the most powerful being in the Universe", so I can only imagine how harmless Hulk will be to him when that confrontation occurs.