Many of you guys have very good ideas. However, Bane is the leading antagonist in one of Batman's most famous storylines: Knightfall; and, of course, he breaks Bats' back in that storyline. I don't really care, but do you think die-hard comic fans would be upset that Bane was used in another film and the "Broken Bat" storyline wasn't used?
yeah I'm sure some would complain, but I think those guys would have to ask themselves whether they want a better Batman movie or a 'more faithful Bane', which is more important. I think they'd be the kind of *****es who complain that Ra's didn't have Lazarus Pits in BB.
It would be cool to see the Arkham breakout if Ra's hadn't already done it in Begins . But oh well, so what. Even the drug Venom, I don't think that would be critical to adapting Bane for film; it's hardly a part of his character or motivation, it was just the gimmick that gave him an easy advantage/weakness and an inverse mirror to Batman (cheating instead of hard training, which doesn't even make sense in the first place. He become the most feared guy in the prison without the drugs.)
I see Bane's primarily qualities as being both a mental and physical match to Batman; being driven to be the 'top guy' wherever goes; having a sense of honour as well as ambition; and being very pragmatic. He doesn't have any lofty ideals or philosophies, he just wants to be the best. Recently in the comics he's worked to improve the conditions of his home country, fighting drug runners and militias, and I'd take that as well and make it a primary attribute. Also the fact that he comes from a totally foreign stomping ground and beats Batman in his own territory, that's very important and distinctive to Bane.
Also Batman can be broken figuratively just as well. Breaking his back means you have to involve replacements (to keep the story going) and then a long period of healing. It takes the story off of both Bane and Batman, detrimental unless you have a really cool replacement lined up (Catwoman?).
Also imo the original story is just cliche at heart, on film it would seem too-obviously contrived and bare-boned; the injured hero returns to vanquish his less worthy rival. Sorry, but I've seen that movie a hundred times. Unless you find a really special way to make it work (like if the director really cares that much about a wheelchair bound Batman) then I don't see why it's so important. It's just a fanboy impulse to see a comic page come to life.