I was thinking more Lois teaming up with Harley and Ivy since they can’t use Cat, and she is an investigator, lady, and played by an actress at her peak who is also onto her role, so that might give the sequel a boost, also its a clash of personality and background as well, makes for good drama.
But a Lois film would be great, with cameos or support from day, Ezra the lab guy, Jena Malone, some cameo from Gal and Jas etc, even Perry White. Stuff Superman, she can have her own film first, esp with Adams in command