The Queen saying something like "I feel like one day the AIs will turn against us" was an odd comment because I'm sure Wakanda was aware of Ultron's existence.
Also I'm only now realizing when she goes "There's something I need to tell you about your brother..." but never finishes because of Namor's interruption was her about to tell Shuri about T'challa Jr. Which is honestly a little confusing because she doesn't bring it up again and one has to assume it after the post credit scene.
So, M'Baku is King. It'll be interesting to see the dynamic between him and Shuri. What if there's a difference of opinion on what the Black Panther should do at a certain point? Technically Shuri is at his orders, though it seems they are in really good terms.
I assume our favorite coloniser, agent Ross, is now a refugee in Wakanda just like Bucky once was. Let's see where the story goes for him.
I was expecting Namor to become a hero/anti-hero by the end of the movie. Him remaining pretty much a villain and wanting to conquer the world will lead to an interesting story though. We'll see when or if he has a redeeming storyline (Ramonda's blood remain on his hands).
Riri now I'm sure has a lot of pressure on her. She can't trust her government or even her school. She's good friends with the new Black Panther. The Queen of Wakanda gave her life to save her. What she's gonna do with this second chance and her gifts will make for a good story on her own show. Nitpicking but I would've liked if she mentioned Tony as an inspiration.
I didn't love the "midnight... something" suits. I hope they don't stay. Okoye and the Doras are already badass as they are. Then again, we have to see if Okoye earns her title again.