To do the Death of Gwen Stacy, you need the Green Goblin. It's already likely not going to be at the bridge (too much like SM1, plus there's a bridge set piece in this).
But I think first, it will be the Machiavellian/Lex Luthor Norman Osborn from the '90s comics to present and not the Jekyll/Hyde persona from the 1960s. That's how they'll separate him in terms of character from the Raimi films. Second, I doubt Harry will appear, which is too bad. But that is one thing the Raimi movies did very well: the Goblin Legacy and Harry's relationship with Peter. It would be retreading familiar ground to redo it in this film series.