This actually looks like fun. Ryan Reynolds sounds hilarious, the kid seems like he'll be fun, I really like the look/feel of the world here, there's several funny jokes just in the trailer, I like the tone that they seem to be going for, and while the Pokémon don't look "realistic" per se, the visual design of them is still working for me actually. It's probably as "realistic" as you can make them in a live action film without radically altering their designs.
Also PLEASE let Ken Watanabe play his cop role straight all the way through. Him talking about Pokémon like it's the most serious thing in the world was both awesome and hilarious at the same time.