Ok, so totally out of the realm of possibility, but one of my favorite episodes of AEMH was "New Avengers" where the Cross Time Kangs broke Kang out of 42.
The regular Avengers were imprisioned by Kang in a temporal void, leaving Earth's defense to a new group of heroes, comprised of:
Spider-Man
War Machine
Wolverine
Luke Cage
Iron Fist
The Thing
I would love to see something like this on screen. It won't ever happen though, because Kang isn't likely to be introduced, with the Chituari being the Skrull-Kree analog, and the effort it would take to bring together this group (with Spider-Man, Wolverine and The Thing's rights being out of Marvel's hands) would be astronomical.