Iron Man doesn't have a Phoenix Saga or an Alien Costume Saga, so for the character, Demon in the Bottle is really his most famous story (although, nowadays, Extremis seems to be coming up right behind it).
I like that Favreau and crew are easing into the story with this film, but I would love to see IM3 definitely utilize Stark's addiction to alcohol as a direct result from the pressures of being a hero and public figure.