Here's what I think will happen with Doom.
Victor Domaschev is a scientist who finds about Reed Richards government funded teleportation experiment when he talks with Reed on his blog. He questions if Reed's experiment will actually work. Reed invites him to come to the presentation to see that it will work. Victor volunteers to join the other 5 scientists testing the teleportation device and he goes through training with the other 5. Him and Reed develop a rivalry. Still thinking the device will not work, Victor makes his own adjustments to the device. Once the device is tested, they are blasted through the N-Zone, changing their molecular structure and giving them powers. Victor does not make it out however. He resurfaces several days later, horribly scarred, with parts of his body transformed into metal. He warns Reed about "the truth" and recruits the fifth scientist, Harvey Elder, who is now transformed into the Mole Man. He uses his powers to take over his homeland of Latveria and plots to destroy Reed.