I'm going to list things that were unique to the Raimi films:
1. Peter in love with the class beauty.
2. The spider being part of a genetics experiment.
3. Peter discovering his powers after passing out.
4. Peter being victim of bullying.
5. Peter gets the great responsibility speech after a minor confrontation with Flash, even though Peter is in the right.
6. Ben's death.
7. The villain acts as mentor to Peter.
8. The film ends with a funeral.
9. The villain discovers Peter's identity and seeks "revenge" for betrayal.
10. Major confrontation on a bridge which involves saving a child/children.
11. The villain has to experiment on himself in order to preserve his life's work.
12. The villain shifts back and forth between normal self and villainous self (In the comics, both the Goblin and Lizard remain in those states until an outside event causes their return to normal).
13. Peter is shy (He isn't in the comics, cartoons or TV series).
I'm tired now, but I'll likely think of more.
1. So what if Peter was in love with the class beauty? They go to the same school, and is supposed to have a crush on her like he did in the comic books.
2. The spider was part of a genetics experiment, but in SM1, it was a "new species" spider that combined several other species into one. The spider in this movie is at Oscorp, and related to Peter's father and cross-species genetics.
3. Peter discovers his powers after passing out, but once again is different. In SM1, he goes home, passes out, and wakes up the next morning flexing his muscles. Here on the way home, he wakes up on the subway on the ceiling and quickly enters a small "battle."
4. Peter? A victim of bullying? WHOA! Sam Raimi came up with that one, didn't he?
5. Really, once again, I'm going to say who cares? Another nitpick. Yes, this is a similar plot point, but once again VERY different.
6. We discussed Ben's death already, and it is not EXACTLY the same as in SM1.
7. Didn't Connors act like a mentor to Peter in the comic books as well?
8. The film ends with a funeral because of the death of the Captain. Not because SM1 ended with one.
9. The villain does discover Peter's identity, but he didn't want to kill him for "betrayal," but because Spider-Man was getting in the way of his plans.
10. Yeah, there is a major confrontation on a bridge. There was also one in X-Men: The Last Stand. Same for many other movies. Once again, another nit pick.
11. Connors experiments on himself to save his "life's work" for different reasons. He wants to find this "cure" in order to get back his arm, and "change the lives of millions." Norman Osborn wanted to test the serum on himself to see if it worked in order to keep the funding for his company.
12. Now here I have a problem with him shifting from his normal self to his villainous self, but as I said many times, the Lizard is my biggest issue with the movie.
13. Peter is shy, but that is a big part of being a nerd or outcast. Also helps him become more relatable.