Yup, Cyclops should be the first main character, in the first season could grow from cyclops and Iceman to the rest of the first class, then use the first class as the main cast for later seasons, in least for the first 3 seasons i would keep the first class and the original classic stories before giant-sized x-men.
Season 2 could have Mimick for a moment, the first half could be centered in the Juggernaut storyline with xavier, but still keeping the mutant of the week episodes, then a mid season twist where the sentinels become the main villains.
Making the sentinels could be difficult but they could make the cyborgs dressed as human like in their first appearance where they were human sized, cyborgs actually work in tv shows if you don't show the robotic interior mutch like in Terminator: The Sarah Connor chronicles and buffy.
Season 3 could have the return of Magneto, make Quicksilver and scarlet witch discover he is their father, show Havoc (cyborg's brother), and end some other things.
After that they could go all new team for Season 4 or for seasons 4 and 5 take things from here and there in the comics to make the characters grow into adults.
Then use the new team of Wolverine, Nightcrawler, Banshee, storm, etc for season 6, or not, it depends on what is done in later seasons