I see them laying out Spectacular-like foundation with the Smythes, and Norman obviously. We haven't got TOO much from Octavius, so I can assume that he will get similar treatment since they decided to de age him to a similar age to Peter (for WHAT?) same with Shocker, as it is obvious they are trying to build him up for something... and kudos for this show making use of Shocker being intelligent enough to create the gauntlets that he uses, something that is even often ignored in comics, unless they have to make a joke about it. Also I can see them doing SOMETHING with the Jackal, being his animated debut in costume/transformation. And also being related to Gwen Stacy in this series However...he's already established as a criminal... so it's not so much of a build up on how he will become a super villain like Miles Warren was in Spectacular, but more so how he will be exposed and how his relationship with one of the main characters will be effected.
I will say that this show also has some similarity to the 90's animated series SO FAR with its treatment of some villains as well... In the 90's cartoon, some villains like Shocker and Rhino were already established criminals, and often were simply hired goons (they didn't even really have names outside of their super powered persona... unfortunately I can see this being the case with the Scorpion in this show. Even Vulture had SOME background (even if it was tell more than show), but Scorpion...I'd love to be wrong, but I don't ever see him being used outside of villain fodder like he was in his debut. Let's hope I'm wrong.
All and all... this show is still pretty "meh" to me....and I'm not looking forward to seeing everyone and their mom getting spider powers.