Harley returns to Gotham City to reconnect with her old friend, Ivy and have some girl time after yet another fight with Joker (he's mentioned but not seen). Together, they erupt through the city on a crime spree which eventually puts them in the cross hairs of Carmine Falcone & his criminal enterprise.
Falcone places a bounty on their heads which is picked up by Gotham City criminals such as Firefly & Killer Moth, to name a few. Catwoman, having heard about the bounty, goes to Harley & Ivy to offer her temporary help--she has a history with him that is teased throughout the story.
Commissioner Gordon and Det. Montoya are hot on their trails. Barbara Gordon, a student at Gotham University, decides to don a cowl after being inspired by the recent reemergence of Batman.
Batman has small appearances/flashbacks throughout the story but he only plays a small role--perhaps he's otherwise occupied with a JLA crisis.
Harley Quinn - Margot Robbie (
Suicide Squad, The Wolf of Wall Street)
Pamela Isley / Poison Ivy - Amanda Seyfried (
Les Miserables, Ted 2)
Barbara Gordon / Batgirl - Haley Bennett (
The Girl on the Train, The Magnificent Seven)
Selina Kyle / Catwoman - Eva Green (
Penny Dreadful, Casino Royale)
Carmine Falcone / The Roman - Ray Liotta (
Goodfellas, Shades of Blue)
Killer Moth - Giovanni Ribsi (
Avatar, Ted 2)
Firefly - Walter Goggins (
Vice Principals, Justified)
Commissioner Jim Gordon - J.K. Simmons (
Justice League, Whiplash)
Det. Renee Montoya - Michelle Rodriguez (
Fast and the Furious, SWAT)
Bruce Wayne / Batman - Ben Affleck (
Justice League, Argo)