Seriously.
It was bad enough when Martha Connors randomly died of cancer in a crappy computer-graphics Spidey limited comic series titled "Quality of Life" back in 2002. The character had been around since 1963, and then she just dies in an obscure experimental Spidey comic that not many people even heard of, much less read.
Then suddenly Curt Connors apparently knows Peter's secret identity for no reason during the Jenkins run on Spectacular Spider-Man in 2003. That apparently got reversed by the "Brand New Day" ridiculousness, but whatever.
Then the Lizard gets his ass handed to him in a battle with the Black Cat, of all people, in a storyline by Roberto Aguirre-Sacasa (who admits to Black Cat being his favorite Spidey character) in Sensational SM from 2006-07. Billy also gets injected with the Lizard formula here, although we never hear anything more about that after this storyline ends.
Then this "Shed" storyline takes the last meaningful thing in Curt Connors life, Billy, away from him and makes the Lizard just another ruthless, killing monster.
The 21st century has not been very kind to the comic version Lizard overall. Maybe the movie will change that.