I'm kind of wondering how that might be handled too.
Let me repost something that got lost in the chaos of the leaked Lizard pics a few days ago...
I've had many debates over the years about how savage the Lizard should be in movie form. Regardless of whether Lizard can talk (which I hope he does, at least at first), or if he becomes a mindless beast, you can be pretty sure that he's going to do some violent things onscreen to establish his villainy.
The question is -- how violent should the Lizard get, and how might his actions impact Curt Connors remaining as a character in the rebooted Spidey franchise?
Should the Lizard get totally animalistic and tear people to shreds and eat them? There's only so far you can go with this in a PG-13 movie of course, but I don't know if I want to see Lizzy killing innocent people right and left. It kind of lessens the sympathy for Connors and reduces the chances that Lizard will survive at the end of the film.