some things I would love to see in the movie to give the movie some dramatic weight;
1. would be cool if the movie focused on conner's utter frustration of only having one arm. maybe have a scene where he is attempting to do something as simple and mundane as tie a tie and breaking the bathroom mirror in frustration when e is unable to.
2. have tention between conners and his wife (purely from his side) she tries to reassure him that the arm doesn't matter but he is obcessed with being whole again and hence willing to dabble in dangerous experiments.
establish extreme motivation.
3. have conners at least have a couple of scenes where he is whole again and just have family time. quiet time with the wife, playing sports with billy. if you really want the audience to empathise with the villian give conners everything make him enjoy it and then take it away in the must heart breaking manner possible.
4. have spidey completely over matched by the lizard. you could have a cool scene where spidey punches lizard and nearly breaks every bone in his hand.
this way all fights with the lizard from spidey's point of view will seem desparate and last ditch. make it clear that when spidey is going into the final battle with lizard it's life or death with spidey having no idea if he can win this but needing to save his friend.
5. have peter discover the identity of conners and when he goes to the conners house (with lizard elsewhere) have a conversation between conner's wife and spidey which essentially has the wife trying to convince spidey not to turn lizard in and spidey trying to convince her that he has to or more people will get hurt.
6. have billy (conners' son) form a report with the lizard so the lizard doesn't attack hm on sight, you can have a really powerful scene where lizard is about to permanantly take spidey out but is stopped or rather distracted by billy.
unfortunately I don't think any of this will happen because the movie will focus on the origin and leave little or no time to explore conners or his family.