Wasikowska has tons of talents but is perhaps not the first choice for Susan that one will think of. She seems so mature-looking these days, more so than other 89'ers.I think Mia would be a great choice. She's a great actress and already has connection to Disney (Alice in Wonderland). So she could possible be on the list to pla Sue.
You know Disney usually casts actors from previous Disney movies like Jude Law (Captain Marvel, Peter Pan, Skeleton Crew), Cate Blanchett (Cinderella, Thor Ragnorak), Richard Madden (Cinderella, Eternals), Angelina Jolie (Malificent, the one and only Ivan, Eternals) and so on.
So Mia could be a potential candidate like other actresses: Lily James (Cinderella), Emma Stone (Cruella)
It can be translated as "motherly", but I have to admit I have some difficulty imagining her in the role.
Let's just say her talent is enough

She can also be a good match for Krasinski.
I never thought about the Disney connection you present. It's an eye-opener! Thanks for bringing this up!
Now you have decoded the studio's secret

And that Wasikowska likely is a secret frontrunner together with Lily James. Any day now, then BOOM, they will reveal it stands only between these two.
It didn't cross my mind that Emma Stone is actually a candidate as well. Really weird considering I usually think of everything lol.
She's really good. I hope that others will pay notice that you mentioned her and then discuss the actress alongside the rest of the suggestions

For me it's just that I personally think Jennifer Lawrence is a better fit for Susan..
(looking at actresses who previously played Marvel characters, that is)