I think they should bring in all the love interests, have Peter have a crush on one, but not get with any of them but have awkward interactions with them all. That mitigates the romance aspect of the story while having fun with it.
Mary Jane - Immediate object of Peter's affection, the new girl who moves next door to him
Gwen Stacy - Childhood friend who is laid back and Peter sees something as a sister, although she doesn't see it the same
Liz Allen - Girl everyone in school wants, doesn't pay Peter much attention until he starts standing out thanks to more confidence
Betty Brant - Secretary at the Bugle, several years older than Peter (lets say 19-21), they sort of have an attraction but it's weird because of the age discrepancy
Felicia Hardy - Black Cat, Spider-Man's love interest more than Peter Parker's.
Bring 'em all in.