I think the biggest loser of 2012 will be X-Men: First Class. The X-Men franchise is looking awfully long in the tooth these days, and I think Audiences are going to be bored of seeing yet another prequel with a predictably status-quo outcome. We all know that by the end of the movie the characters will all end up where they were at the beginning of X-Men 1, so much like Wolverine there will be an inescapable sense of predictability. Add to that the lack of familiar faces, and it's easy to see it getting lost in the shuffle of fresh new licenses like Tor, Captain America, and Green Lantern.
I have a bad feeling about Captain America, though. I have high hopes for the movie's quality, but I'm worried that it's potentially a big bomb in terms of box office. The Cap just doesn't have the kind of recognizeable powers that a lot of other heroes have, and on top of that the movie will probably do poorly overseas since a lot of countries still see Captain America as a propaganda tool. Unless the movie does REALLY well in the US, it's going to be in for a tough fight.