I seem to be the only one who doesn't really find Mikkelsen all that obviously creepy.
He acts relatively "normal", to me. I dunno, I don't get the "obviously a monster" vibe. Agree to disagree, I guess.
Hopkins is a lot more "wink wink nudge nudge" overtly creepy (not to mention hammy) in the prologue of Red Dragon where he's hosting a dinner party in high society and isn't known to be a killer yet, than Mikkelsen was in the pilot episode, to me.
I mean, Mikkelsen has moments, like when he leans forward and tells the patient the line about how he'll know when the lion is in the room, and the way he (probably) feeds Graham the girl's lungs, but he plays that breakfast scene more subtle and low-key than Hopkins was in the Red Dragon prologue where the symphony board is obliviously chowing down on the missing flutist and someone asks Hannibal what the meat is and he says ever so very winkingly "If I tell you...I'm afraid you won't even try it". Hopkins almost literally gives this giant wink at the camera.
I love Hopkins as Hannibal, don't get me wrong, but he was enormously campy and way more over-the-top than Mikkelsen so far, including in the Red Dragon prologue where he's in the same "mode" as Hannibal is on this show...the respected psychiatrist who hob knobs with high society and isn't known as a killer yet.