I'm cautiously optimistic, in part because I love anything Ghostbusters, but also because the only way I can see Reitman really wanting to do this, especially after the 2016 movie, is if they were getting the band back together.
I think Akroyd, Hudson and Murray will almost certainly be in this. Murray doesn't want to be a Ghostbuster? Well, neither did Peter Venkman, really, outside the cartoons and comics. It's the perfect material to mine for his character's screentime.
I'm fine with a passing of the torch concept, as long as the original guys get a moment or two to shine. If there's a kid or two, then there's a kid or two. There's mileage yet in the hero worship cocept. Oscar was one of the more charming elements of GB2, and he was a baby (or two).
Prepare yourselves for the Ghostbusters multiverse, or at least a nod to it, though. It's coming.