I think beginning in No Way Home and then concluding in Multiverse of Madness, a singular 616 timeline will be established and I think that’ll bring with it some familiar faces. Deadpool, for one (he could be the MCU’s Psycho Pirate, tbh). Maybe 616 is aptly named because Strange and his team of sorcerers manage to save 616 strands of reality & bind them together which causes some multiversal bleed.
And I could see Hugh Jackman returning too as an older mentee/drill sergeant (like in X-Men: Evolution) at a newly-established Xavier Institute in the MCU. Recast the rest of the mutants, but Jackman is this Logan too just cause. Laura can assume the mantle of Wolverine when Jackman decides he’s had enough fun playing in the superhero sandbox again—at least until after a Secret Wars crossover.
Again, like in Evolution, put him in multiple versions of the costume and people will be excited.