With the 'Dark Knight' ref , I just hope it means a serious drama set in a more realistic world, not that Spidey should be a grim character. Sure, there are many depressing aspects to SM comics, an issue would usually end with PP bemoaning his current lot in life, but Spider-man should be recognisably a humourous character, using that to get through his problems.
The first Spidey story was pretty 'gritty' and realistic, if they are going with something close to a 'real world' take, it would be cool to see Spidey go the tv star route as in the original origin, probably what would happen if a teenager got superpowers.
In fact that's what the original Lee/Ditko stories were about, giving powers to a normal kid with real life probelms in real situations. So the 'Dark Knight' ref may not be so off the mark, as that is the most recogniably real world superhero flick.
Make it a 2 and a half hour epic, 1st hour for the Amazing Fantasy origin done ultra faithfully, yes, he must discover his agility and sticking powers jumping out the way of a car, I missed that bit from the 1st movie.