I used to get the original Spider-Woman comics when I was a kid, don't know what she's portrayed like these days. But in the original comics it was pretty interesting, because of her 'spider-nature' people would shy away from her and not trust her etc. so no friends. But she had a boyfriend, Jerry something, who was a law agent of some kind, and for some reason he was not affected by her power to 'repel'.
That could make for a really interesting superhero movie, something that's not been seen beofre onscreen.
It could be a bit too much for audiences expecting a light hearted Spider-man type film, so could bomb even if it was a good movie, but if it had the requisite action it could alright.
As for who to star and direct this type of SW movie, David Fincher would be good, he was interested in doing Spider-man back in the 90s but said he would have wanted to make it a dark take on the character, so not right for SMN but right for this kind of SW movie.
As for starring, Angelina Jolie could do it right, but I'm kind of tired of thinking of her for roles, or maybe Joelene Blalock from Enterprise.