It's feasible, but with all the other weird age issues with the cast, it makes more of a mess of things than is necessary. As it is, not only did Sam have Lois when he hadn't even graduated from high school or become old enough to enlist in the army, Lois herself would have been a relatively young mother.
Bitsie/Lois is 39, while her sons on the show will be high school freshmen (14/15). That means Lois likely had them when she was 25. Now that is typical for plenty of women, but not Lois Lane. Lois is usually working at the Daily Planet a few years before Clark arrives, and it usually takes them at least a few additional years to get serious enough to get married. Both of them struggle not only with what it means to be intimate and trust because of past emotional issues, but also with balancing their personal lives with their dedication to the "never ending battle," so to speak.
If she and Clark had the boys at the ages suggested, all of that talk from Clark to Kara in his first appearance about how hard it was to figure out a balance between the two sides of his identity (and that's when he was only just dating Lois after years of knowing her) is gone and replaced by someone who actually got his act together with relative ease. It also places Lois as a young mother having to take care of two young children—one of whom (Jordan) the pilot tells us was troubled and difficult—while in the prime of her career when she's usually reporting on crime or from war zones. The pilot also suggests Clark kind of left her to it ("Lois...took over...while I made the world a little safer....").
It also means that he wasn't some bachelor who was still figuring things out when Kara arrived. If Kal was in his 20s when Kara arrived on Earth, Kara became Supergirl roughly 10 years later, and the twins are in their teens, that means that Kal was already a father when Kara arrived. Instead of being dumped with the Danvers, she could have easily become part of his family and helped raise his sons, as she would have done for him had he still been a baby like she had been expecting. Moreover, if one is to take the Argo location for the conception and birth of the boys, then one is left wondering how, without it, Lois and Clark were even able to have children.
In short, the ages work in a general or abstract sense, but the way they compress the timeline for these characters isn't ideal. To me, it doesn't resonate with how these characters are typically developed in the broader Superman mythos.