I'm actually kind of excited for this new origin. Then again, I'm pretty susceptible to change. It doesn't bother me one bit. And while I'm a huge Spider-Man fan and want things to remain faithful to the comics, it's always nice and refreshing to get acclimated to something "new".
I feel Marc Webb knows what to do. This is kind of a modern retelling of Spider-Man. He is making it so that the same lessons taught 50 years ago can be translated well to the people of modern day.
I think the new origin is actually kind of interesting and allows a little more depth. Instead of being an accident, there is a purpose. Like other posters have said, I think Peter is Richard's black box. He hid his research inside Peter hoping that one day, Peter will unlock the secrets he kind of holds. I think this is one of the reasons why Doctor Connors is so excited to see him.
And I know a lot of people are questioning Doc Connors thinking he is going to be bad the entire film...maybe he will be. While it does suck that it's different then the character we've become accustomed to...it makes sense. Like he says in the trailer.
"Your father and I were going to change the lives of millions, including my own."
Then Peter came along and Richard abandoned the research. It kind of makes sense, to have that promise stripped away from you. I think anyone would have a little animosity/resentment towards that fact.
I think this film is definitely going to deliver on all fronts. Though I don't think it's going to be a huge box office success story. It's going to do great but I think the sequels are where it's really going to shine. This film has so much adversity to overcome. Adversity that I honestly don't understand.
A lot of people bashed the Raimi films and now they are getting something that seems to actually understand the character, even though tweaks are made, and they grab their pitch forks and torches?
Garfield and Stone will prove that they are the definitive actor/actress for the roles. I'm willing to bet people will be blown away by their performances. And then people will get excited for the sequels to come.