Apparently, it's been the experience in Marvel RPG's that leaving off with current Marvel continuity kills the RPG prematurely. That's why we called this 10 Years Marvel where it's 10 years since the origin (leaving origin stories optional so we aren't bogged down with solo arcs), everyone is able to pick and chose what they want to have happened to their characters, and everyone can get to the action.
I definently feel like events like Civil War, Secret Invasion, and maybe even Dark Reign to an extent add too much strain to prospective talent. But, personally, I don't care and I think we could all work around it. That said, I do whatever possible to not force people to accept things from which they may be turned off.