Nah. I couldn't care less, but Spidey fans as a whole are anal-retentive about continuity even outside of the 616 universe, in which case I think it's best to chillax and let a wholly different story unfold than try to make everything perfectly reflect the original comics. That's not to say I'm without reservations for this movie, however.
I'd rather not see Cindy Moon in general though, other than just a fun wink-wink namedrop because I don't see Silk getting her own movie and I don't want an Ant-Man & The Wasp situation. From my admittedly limited reading experience, Silk is not a character that I personally am clamoring to see on the big screen--at least not yet.
Not necessarily. Just means it won't unfold as it did in 616 universe, which is good as we already saw a moderately faithful version of that in TASM series. I love ASM 121-122 and all, but I'm not super excited to see Gwen die again, especially when that was one of the few things I thought TASM2 did extremely well.
There's still a chance we get Gwen in future MCU Spidey adventures, just don't expect green coat and purple skirt IMO.