If they were to go that route my strong preference and advice would be to:
A) Have the new version already be established as being Spiderman, for at least several years. Don't put him back in highschool . Maybe Grad school at the most, and most of his rogues gallery should already be established.
B) Don't redo the origin again, even in flashbacks. People know his origin after 5 films, and I think another reboot goes over alot easier if you don't waste time showing him become Spiderman, uncle Ben being killed etc all over again.
C) Don't go back to the Osborns and the Goblin saga, let alone the stuff about his parents.