i agree.. I've always seperated spideys villains into basically 3 groups...
Group A ) these villains tend to effect both sides of peters life, spidey and parker. They're his most compelling villains... and if they don't effect the parker side, there stories, psychosis, and challenges they give spider-man are top notch... they include... Green Goblin, Hobgoblin, Venom, Lizard, Doctor Octopus, Carnage, Scorpion (though scorpion himself is a thug (see part C) the psychosis, insanity, and hatred for jameson makes him pretty compelling)
these can all hold a film by themselves...
Group B ) these villains are compelling... but get a little more "umph" if partnered or have a little help... they can work solo given the right story.. but it could be a difficult task Kraven (kraven tells a great story, but i think he's enhanced even more with the likes of Calypso, Chameleon, Vermin or Lizard, or the rest of his family added into the mix.), Jackal (though wont be used has always had a few henchmen.. be it tarantula or punisher), Chameleon (works best in a mafia or his half brother kraven), Kingpin (kingpin as much as i love him, needs his men for hire), Mysterio (Mysterio can work on his own.. and works best on his own aside from sin six, but he's a difficult story to craft. I say go the broadway route over hollywood. But either way he needs to torment spidey)
Group C ) these villains are THUGS.. plain and simple, they don't need a whole lot of development.. these are people who are career criminals who just so happen to have great power.. and act irresponsibly. Sandman, HydroMan, Electro, Vulture, Hammehead, Rhino