The way I am looking at the movies(and potential nolan trilogy) is that by the end of the third movie BM will have been through the wringer with his own sense of identity and relationship with the people of Gotham and will be the established order by the end of the third setting him up for James Bond type adventures afterwards, ie new villans, new places. The challenge for other filmakers will be to make his character anywhere near as interesting as he was when he was trying to find his place in the world and his sense of himself.
Pitting him against folk with superpowers, yes, I could go for that, it could be fun and also give his character something new to wrestle with. I always thought there was some ambiguous feeling kept around teh Ras of BB that he could have a toe in the supernatural, I could accept some sci-fi or mystical elements coming into play.
I'd also like to see him go outside of Gotham, yeah it's his perfect backdrop, but I've always liked stories like the first Ras Al Ghul one where we see Bats in different locales and other folks reactions to him who have never heard of him.
We shall see, but unfortunately the material could very easily go south if not handled well. Hell, one of my fav BM stories is 'Murder in the Night' from 1978, a great detective story where BM messes up and only survives due to dumb luck, but also has the villan putting his mind into the body of a Gorilla. That's the thing, if the story and dialoge are top notch I can handle Bm being up against the more outlandish, and that rooftop fight with teh Gorilla, great fun to read, could be even better on film.