Entertainment Weekly reports that Marvel and ABC are planning to launch another series featuring characters first introduced in Agents Of S.H.I.E.L.D. Which characters? No idea, as all plot details etc are still under wraps, but we do know that S.H.I.E.L.D exec producer Jeffrey Bell (Angel, The X-Files) and series writer Paul Zbyszewski (Lost) are involved. Plus, apparently some story elements that are still to come on S.H.I.E.L.D. this year will be used to "lay the groundwork for the potential new series".
http://www.ew.com/article/2015/04/09/shield-spinoff
http://www.ew.com/article/2015/04/09/shield-spinoff