Well, not only do I think it's obvious that Aunt May and Jay Jameson are the ones who are going to get married, but that Doc Ock will crash the wedding. Well, consider the following purely speculative scenario:
Doc Ock, like everybody else in the world, saw Spider-Man reveal his true identity on live television. Everyone was made to forget that Peter was Spider-Man, but they probably still remember that he still unmasked (there was that status quo blurb in issue #546, remember?) So Doc Ock, being the intelligent person he is, probably knows that he, along with the rest of the world, knew who Spider-Man really was, and that has to irritate him more than anything. So how can he rediscover who Spider-Man is?
Enter those weird glowing green things with tentacles following Spidey around at the end of issue #594--things which not only had a kind of cephalopod-like appearance, but didn't seem to trigger his spider-sense. Perhaps, Doc Ock created these devices to track Spider-Man via locking on to his spider-sense and, simultaneously, block the spider-sense from detecting them. However, thanks to the "psychic blindspot," Doc Ock is still unable to learn who Spider-Man is despite the "cephalopods" tracking him--but he can, at least, pinpoint where he is, and it's enough to at least learn that Spider-Man is closely associated with Peter Parker and his family and friends.
Naturally, he learns the announcement of Aunt May and Jay's wedding (and of course he still fondly remembers May) and interestingly enough, J. Jonah Jameson, the mayor, along with several important political figures and New York's upper class will be in attendance. And since, thanks to the "cephalopods," he knows that since Spider-Man is also connected with this gathering, he will be there as well. This is far too good an opportunity for him to pass up.
So, Doc Ock shows up, right at the moment Jay and Aunt May are about to exchange vows, and after dispatching a few "fools" attempting to stop him, he holds the entire wedding hostage, and reveals that he knows that Spider-Man is secretly in attendance. Maybe he even reveals the fact that Spider-Man's identity was once public knowledge and how strange it is that everyone has now forgotten just to throw in doubt and suspicion among the hostages along with the fear and panic they must also be feeling. Then Doc Ock gives an ultimatum: if Spider-Man doesn't reveal himself within the next five minutes (or whatever time-limit he imposes), he's going to kill four random hostages--one for each arm-- and keep doing so for every five minutes after until Spider-Man comes forward.
Eventually this leads to a fight between Spidey and Doc Ock in which, in an effort to try and help Spider-Man, Jay Jameson ends up either dying or critically wounded and in a coma. Because you see, that's what I believe Jay Jameson's purpose is--to get the readers all thinking he's the "the greatest senior citizen on the face of planet Earth," with all the characters we sympathize with liking him and all the characters we love to hate despising him, with everything he does designed make him out to be good, decent, and pure--only to then either kill him off or have him seriously injured and "knocking on heaven's door" in order to generate further sympathy for the characters, be shocked at the tragic turn of events, and generate more conflict. Which is usually what Mary Sue and Marty Stu's (and make no mistake, Jay Jameson certainly qualifies as one) are often times designed to do.
Think about this: if Jay "Marty Stu" Jameson dies or is critically wounded on the day he is supposed to marry Aunt May, look what that creates.
*It makes Spidey grieve and feel indirectly responsible over another father figure being hurt because of his life as Spider-Man.
*It brings back the old "I can't stand that icky Spider-Man" from Aunt May, who now has a legitamate reason to really hate the wall-crawler because his interference cost her the second man she ever truly loved, and thus Peter feels he can never reveal he's Spider-Man to her.
*It ramps up Jonah's hatred for Spider-Man because now the wall-crawler cost him his father just as they were starting to reconcile (oh, and you can bet that's going to happen, most likely in the upcoming Amazing Spider-Man Annual which is also related to the wedding of Aunt May and Jay Jameson.)
*It allows Jonah to still interact with the Parkers because he'll want to take care of the woman who almost became his stepmom.
*And, if Jay is simply in a coma and about to die, perhaps it will be used to recall when Aunt May was hospitalized and about to die and how she was miraculously cured. And who do we know who has healing powers and is also someone Aunt May works for? Why, Martin Li, a.k.a. Mister Negative. That's right--this could be used to partially explain how Aunt May was healed via One More Day while simultaneously revealing his origin.
So basically, it's going to be presented as a happy occassion but, in true classic Spider-Man fashion a la the "death of Captain Stacy" (which I believe Dan Slott was quoted as saying that was the first Spider-Man story he ever read) it's very likely going to turn into the whole "Spidey wins the day but at a great personal cost in which everyone hates him."