Spider-Man 2099 vs. Frankie Raye:
Again, first a breakdown of each character's powers.
Spider-Man 2099:
Abilities-Superhuman strength, speed, agility, reflexes, and durability
-Accelerated healing
-Enhanced vision
-Retractable finger and toe talons that enable clinging to many surfaces
-Organic webbing from forearms
-Paralyzing fangs.
Frankie Raye:
Powers Nova could manipulate cosmic energy in the form of stellar fire, surrounding herself in a flaming aura. Her portion of the power cosmic allowed her to manipulate all forms of energy, fly at warp speed, and survive in outer space.
Also to note:
Strength Level: Nova can lift about 40 tons.
Now, prep-time will seem to slightly benifit Spider-Man 2099 more; since, he comes from the future. But, if you are aware of the time that Miguel comes from, you'd know that information about past heroes isn't that easy to find. The political leaders are very much against glorifying superheroes from the past, and having memorabilia about them is considered just as bad as if police found drugs in our homes. Simply put, it's against the law. Now, there is a chance that Miguel would know a bit about Nova II(Frankie Raye), since he really liked to follow the past exploits of many past heroes...but, Nova II's role as a herald of Galactus probably wouldn't have been mentioned much.
On Frankie's side, she'd know nothing about Spider-Man 2099; but, she'd be fully aware of who Spider-Man is. This would give her some awareness of Miguel's powers.
Now, let's focus on Miguel's powers, and why they would effect Nova II that much. First, "[Spider-Man 2099] has the proportionate strength, speed and agility of a spider, which allows him to lift many times his own body weight, perform complicated acrobatic and gymnastic maneuvers that would be impossible for even the most highly-trained athlete, and jump great distances." While impressive, it doesn't compare with Frankie Raye's ability to lift 40 tons and fly at warp speed.
Second, "[Spider-Man 2099's] durability was also increased to a point where in an issue he suffered a punctured lung, broken ribs, major abrasions and bruises, and made it to a hospital in time where a doctor told him he has amazing constitution for him to be alive. He also notably heals faster than a normal human, but does not have a healing factor (he would not have needed a doctor if he did)." Also impressive, but Nova II was made by Galactus to withstand the effects of space, and as the following biography states, "(as herald of Galactus) ability to survive in a vacuum, superhuman strength and durability," which I'd easily infer as to be quite extensive, much more extensive than Miguel's.
Third, I want to point out one important part of Miguel's powers that he doesn't have: "Notably absent from his suite of powers is a "Spider-Sense." That really is a big deal. One of the things that gives Spidey an advantage over many of his foes is his spider sense, and since Miguel doesn't have this, he's at a humongous disadvantange.
Fourth, "
Spinnerets in his forearms enable him to fire organic spider-webbing from the top of his wrists, usable in a wide variety of ways. Like his predecessor, Spider-Man 2099 can travel at high speeds swinging on "weblines" when necessary, and he can use his webbing to ensnare enemies. Retractable talons in his fingertips and toes enable him to climb walls or cut enemies." Again, this is totally cool, but Frankie Raye has Cosmic Powers which would cause her fires to burn the spider-webbing quickly away. Plus, while Miguel's talons have cut through some metal in the past, Frankie Raye would be much more durable than that. Plus, climbing and fighting won't be very effective to one who can fly above such assaults.
Fifth, "He possesses venom glands and slightly enlarged, pointed canines (which are not entirely dissimilar to a vampire), which allows him to paralyze his foes should he choose to bite them." He would simply break his teeth trying to bite into a cosmic being, like Frankie Raye. Again, another power negated.
Finally, "His web cape, which he obtained from a Thorite (Worshiper of Thor), is made from the Lyte Byte material commonly used in the manufacturing of hang-gliders, and acts as an air foil, allowing him to glide on air currents for a short period of time, as well as slow his rate of descent and control his direction in freefall." Now, this is totally cool, but ineffective in this battle. Frankie wouldn't drop Miguel from high in the air, since she's basically one of the good guys, same as Miguel. But, a fight in the air with gliding abilities wouldn't help Spider-Man 2099 in the least bit.
So, that shows pretty much how all of Miguel's powers are completely useless in this fight. Frankie has the advantage with flight, and wouldn't even have to worry that much with an airborne assult. Sure, Miguel could shoot some webbing at her; but, her cosmic powers would easily make them disappear.
Winner = Frankie Raye(Nova II)