You know I've always been a fan of MJ and the marriage (one of the many reasons I stopped reading the comics) 
But this Gwen is just so damn likeable.  I watched a couple episodes, and I found myself really digging this version of Gwen, then it hit me...  "Oh $#!*, she's Gwen Stacy!!!!, this won't end well."
I grew up after the death of Gwen (I'm still probably way older than most of the rest of you)  And I always respected what her Death meant in the context Spider-Man's history (a long time ago I tracked down copies of AMS 121 and 122)  But it hasn't been until now that I really understood the emotional impact of her death, because I just don't want to see this Gwen die.  It's quite sad watching this show and "knowing what's going to happen"
I say don't kill her.  They don't have 40 years worth of stories to tell, I REALLY hope I'm wrong but with being shoved on an obscure Disney sub-channel I think they'll be really really lucky to make it to 3 seasons (and that awfull cheesetastic TAS made it to 5 or 6, ugh, there is no justice)  Which means killing Gwen would probably be one of the last things to happen in the series.  and really, that's a really bitter depressing way to end the show.  
I think it's ok if Gwen gets a happy ending in at least one continuity.