"We’ve always said if there’s any “secret” it’s respect the source material, understand the source material and then, any adaptation you make from the source material should be done only to enhance whatever the original pure spirit of the source material was." Kevin Feige
I believe these are words to live by. Do some revisions need to happen? Sure. But we shouldn't start by saying: "What can we change?" That's Fox-think. We should start by saying: "What can we keep?" and only make changes when they're needed.
Why does Clark Kent have to be a reporter? Why couldn't he be the captain of a nuclear submarine or a missionary building schools in Africa or a neurosurgeon?
Because he's a reporter. That's Clark Kent's Job. That's the character that comic book readers came to love and want to see now. If the original authors had made him a neurosurgeon, that probably would have been fine. But they didn't and that's not who he is now.
Sue as an MD? Sure. I can live with that. At least she's not 'Reed-lite', but why not just keep her an actress? What's wrong with that? Reed and Sue can't have a 1960's relationship. That has to change. But there's nothing wrong with being an actress. People do that in 2016.