What Matt means is that there has never been an on screen villain that has had deep personal ties to Bruce and his past in the way that he’s doing. The closest thing to that was Nicholson’s Joker with him being responsible for killing the Waynes.
The most obvious villain is Hush and it really is a very good twisted story. Thomas being responsible for inadvertently putting a hit on Edward Elliot. The Waynes are mysteriously killed afterwards. Both Tommy and Bruce grow up on separate paths until Riddler reveals what happened. Now, like Bruce, Tommy seeks to avenge his father.
You know what would be even more twisted? If Tommy is actually Bruce’s half brother because Thomas had an affair with Tommy’s mom. Then Tommy was actually named after him and this is why he was drawn to the medical field.