Some non-sequel titles I'd like to see
Runaways
It is pretty popular and critically acclaimed. It doesn't usually make it for long stretches, but neither did Guardians of the Galaxy. Its an interesting take on the grander MCU world, where this cult of supervillains already exist and cover multiple genres of sci-fi and fantasy. On a side-note, it is a sure fire way to add more diversity all at once.
New Warriors
Similar kitchen sink approach as the Runaways. Heroes with varied origins: alien intervention, lab experiments, Atlanteans, hi-tech gear. The most recent iteration even had a clone, an inhuman, and a demi-god.
Agents of Atlas
Another kitchen sink team. I like the idea of this one because they predate the Avengers, and the way Fury introduces the Avengers Initiative sort of makes it seem like something that has been on his mind for a while. Like maybe the tried and messed it up once. Plus the time period between WWII and Iron Man could use some fleshing out.
Werewolf by Night vs Moon Knight
Remember when Werewolf By Night was one of the first proposed Marvel movies back when they sold off a bunch of licenses to stay afloat? That's a random title. I like Moon Knight though, and I always thought his career as a werewolf hunter was shortlived, especially when they later added a power where he got stronger the fuller the moon got. Maybe it'll help differentiate between Daredevil and the inevitable new Batman movies.
Future Foundation
They don't have Fantastic Four, but maybe they can sneak by with the FF. Ant-Man (Lang) ran it for while, and since Hank Pym was the head of Avengers Academy, he could sort of be the new founder, the Michael Douglas version that is. A Hulk? Sort of. Inhumans? Yup. Power Pack? I think so. Dragon Man? Probably. Human Torch? The Jim Hammond version anyway. A decades old Android would definitely get their interest.