Alex Wilder -- Percy Daggs III -- The hair at first, but checking out this guys performance, he's got all the subtleties necessary to insinuate evil while doing all the right things.
Nico Minoru -- Maggie Q -- Talented through and through.  A bit old at 26, but so are most of the asian actresses out nowadays.  I just like her eyes. 
Karolina Dean -- Michelle Trachtenberg -- Tall, beautiful, looks good blonde, and I simply see her in this part and owning it happily.  And I'd buy her as a lesbian... you know what I mean.
Gertrude Yorkes -- Daveigh Chase -- Something about the whole dumpy-girl who is secretly hot really sticks with her, not to mention the intrigue of the combination of a long filmography, smart sassy characters and the creepy kid from horror movies.  I see her doing Gert serious justice.
Molly Hayes -- Dakota Fanning -- Watch one of her movies.  Any one.  She's devestating.  She puts all other actresses to bed.  Even those three and four times her age.
Old Lace -- Andy Serkis :P -- Actually, I'm kinda series, this guy GETS animalistic gestures, and having him in charge of Old Lace's head turns, position changes and general gait and reactions would be a VERY good idea.