You should read through the Dark Angel Saga from Uncanny X-Force if nothing else (first 17 or 18 issues). Amazing story, and Remender's pulling from it for this arc. Plus, it doesn't require any previous reading.
Despite any distaste one might have for X-Books, if you're a fan of just good quality storytelling, art, and characterizations, it's worth a read. What follows after that, while still good, never quite lived up to what came before.
I thought Remender created some fantastic new characters with the new Horsemen of Apocalypse in that run, which is why I'm a little frustrated that he just killed them off willy nilly in Uncanny Avengers. It's seldom that we get High Quality characters that can really have legs nowadays. Hopefully he has more plans for them.