Stan Lee never criticizes other peoples interpretation of his characters so it's unlikely he would say if he was disappointed. My point was that he understands Spider-man better than Sam "stopped reading comics as a child" Raimi ever will.
And yes organics is a huge step backwards for the character. Spidey loses some of his humanity and sophistication. With organics, Parker has spider physiology giving him spider parts and organs. Simply gross and out of character. With organics Spider-man is also less sophisticated. Synthetic webbing is an invention that adds immensely to the Peter Parker/Spider-man character. He's a scientist who contributes something original to his crime fighter identity and arsenal. He a sophisticated superhero who is not just a one-note superpowered freak. Organic spidey just puts on his costume and fights crime. He relies completely on his super-powers. Stan Lee's Spider-man relies on his brain power to defeat mad scientist and super geniuses. That's the way it's meant to be. Dr Ock and Green Goblin have technological weapons and so does Spider-man. Do you think this is a coincidence?
Stan Lee's Spider-man is a thinking man's hero and a problem solver. His intelligence and lack of spider physiology retain his humanity. Sam Raimi's Spider-man is a hairy palmed, web squirting freak who relies on dumb-luck and is a literal interpretation of "spider"-man.

Gone from the character is the technological achievement, the sophistication, and the metaphysical concepts. Replaced with predictable and uninspired spider powers that a child could've came up with. With organics, Spider-man is half the man he used to be.